Systematic Review: Your Question
Preparation Tasks
Developing a Research Question
As with any research, the first and most important decision in preparing a review is to determine its focus. This is best done by clearly framing the questions the review seeks to answer.
Good review questions often take time to develop, requiring engagement with not only the subject area, but with a wide group of stakeholders.
Well-formulated questions will guide many aspects of the review process, including determining eligibility criteria, searching for studies, collecting data from included studies, structuring the syntheses and presenting findings.
Systematic and other reviews will use a recognised framework to help them develop both their question and search strategy.
More Information
Existing Reviews
Once you have defined your question you can start the searching process. The first step in searching for studies is to locate previously conducted reviews in your area of interest. This has three main purposes:
- To verify that your question hasn't already been answered;
- To verify that there are no other review protocols registered with researchers already looking at the same question;
- To identify related reviews that will need to be accessed so that you can review the reference lists for relevant primary studies.
Useful databases for identifying reviews
- Cochrane CollaborationThe Cochrane Collaboration is a not-for-profit organisation with collaborators from over 120 countries working together to promote evidence-informed health decision-making by producing high-quality, relevant, accessible systematic reviews and other synthesised research evidence.
- Campbell LibraryThe Campbell Collaboration maintains and disseminates systematic reviews in education, crime and justice, social welfare and international development.
- PROSPEROPROSPERO is an international database of prospectively registered systematic reviews in health and social care. Key features from the review protocol are recorded and maintained as a permanent record. PROSPERO aims to provide a comprehensive listing of systematic reviews registered at inception to help avoid unplanned duplication and enable comparison of reported review methods with what was planned in the protocol.
- PubMed Clinical QueriesClinical Queries offers a user-friendly approach to evidence-based searching on the Medline database.
- Database of Abstracts of Reviews of Effects (DARE)The Database of Abstracts of Reviews of Effects (DARE) contains details of systematic reviews that evaluate the effects of healthcare interventions and the delivery and organisation of health services. DARE also contains reviews of the wider determinants of health such as housing, transport, and social care where these impact directly on health, or have the potential to impact on health.
- EpistemonikosEpistemonikos is a collaborative, multilingual database of health evidence. It is the largest source of systematic reviews relevant for health-decision making, and a large source of other types of scientific evidence.
- JBI Evidence SynthesisJBI Evidence Synthesis seeks to disseminate rigorous, high-quality research that provides the best available evidence to inform policy and practice through the science and conduct of systematic and scoping reviews.
PRISMA Checklist
Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) is an evidence-based minimum set of items for reporting in systematic reviews and meta-analyses. PRISMA primarily focuses on the reporting of reviews evaluating the effects of interventions, but can also be used as a basis for reporting systematic reviews with objectives other than evaluating interventions (e.g. evaluating aetiology, prevalence, diagnosis or prognosis).
PRISMA for Searching
The PRISMA extension for searching was published in 2021. The checklist includes 16 reporting items, each of which is detailed with exemplar reporting and Rationale.
PRISMA for Scoping Reviews
The PRISMA extension for scoping reviews checklist contains 20 essential reporting items and 2 optional items to include when completing a scoping review.
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